The research of Professor Łukasz Jaremko is focused on atomic-level insight into essential and topical questions of biochemistry and molecular medicine.
Biomolecular nuclear magnetic resonance (NMR) spectroscopy is the key experimental technique used and developed in the lab to tackle challenging macromolecular assemblies. The NMR-based structural studies are often combined with molecular biology and other state-of-the-art biophysical techniques: X-ray crystallography, circular dichroism, and molecular dynamics simulations.
The cutting-edge biological NMR spectroscopy gives access to both structure and dynamics, thus providing information on the functioning of essential macromolecular systems and their mutual interactions under close-to-native conditions (like aqueous solutions at physiological temperature, lipid membranes, living cell environment). The mutual complementarity between NMR and remaining powerful high-resolution experimental techniques (X-ray crystallography and cryo-electron microscopy) paves the way to a more complete description of the pivotal biochemical processes of life and disease.